narna - naRNA-LL37 composite DAMPs define sterile NETs as self ... - PubMed vo777

naRNA-LL37 composite DAMPs define sterile NETs as self-propagating ...

naRNA is a RNA associated with neutrophil extracellular traps (NETs), which are web-like structures formed by neutrophils to fight infections. naRNA can activate TLR8/Tlr13 receptors and trigger pro-inflammatory responses in various cells and tissues, especially in psoriasis.

naRNA-LL37 composite DAMPs define sterile NETs as self ... - PubMed

Our study highlights TLR-mediated RNA-LL37 sensing by PMNs as parts of a self-propagating vicious cycle that may later engulf pDC and establish chronic inflammation in psoriasis and NET-associated RNA (naRNA) as a physiologically relevant novel component.

naRNA-LL37 composite DAMPs define sterile NETs as self ... - PubMed

Our data highlight naRNA as a novel composite DAMP signaling and amplifying neutrophil activation. Moreover, naRNA emerges as the likely driver of inflammation in conditions previously linked...

Neutrophil extracellular trap-associated RNA and LL37 enable self ...

We here characterize naRNA (NET-associated RNA), as a new canonical, abundant, and unexplored inflammatory NET component. naRNA, upon release by NET formation, drove further NET formation in naïve PMN, and induced macrophage and keratinocyte activation via TLR8 in humans and Tlr13 in mice, in vitro and in vivo.

naRNA is a canonical neutrophil extracellular trap ... - Semantic Scholar

Our data highlight naRNA as a novel composite DAMP signaling and amplifying neutrophil activation. Moreover, naRNA emerges as the likely driver of inflammation in conditions previously linked to NETs and extracellular RNA, suggesting blockade of TLR-mediated RNA sensing as potential new intervention target. !

The Chronicles of Narnia: The Lion, the Witch and the Wardrobe - IMDb

naRNA is a RNA associated with neutrophil extracellular traps (NETs), which are web-like structures formed by neutrophils to fight infections. naRNA can activate immune cells and induce skin inflammation via TLR8/Tlr13 receptors, suggesting a new target for inflammatory diseases.