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Deciphering the role of V88L subs... preview & related info - Mendeley

Deciphering the Role of V88L Substitution in NDM-24 Metallo-β-Lactamase The New Delhi metallo-β-lactamase-1 (NDM-1) is a typical carbapenemase and plays a crucial role in antibiotic-resistance bacterial infection.

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Functional results showed that V88L did not significantly increase the resistance level in the NDM-24 transformant toward penicillins, cephalosporins, meropenem, and imipenem.

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Figure 4. Cartoon model of NDM-24. To acquire a credible model, the 6 NDM crystal structure (NDM-1(5N0H, 4RBS, 4HKY, and 4EYL) nd NDM-5(6MGY, and 4TZE)) were adopted. The residue 88L and active pocket were labelled. - "Deciphering the Role of V88L Substitution in NDM-24 metallo-β-lactamase"

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The V88L substitution occurred in the β-strand and low β-sheet content in the secondary structure, as evidenced by the CD analysis data. In conclusion, the V88L substitution increases the...