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Molecular detection of the New Delhi metallo-β-lactamase clinical ...

In the process of NDM evolution under an environmental pressure selection, V88L/M154L combination appears to be favorable (Bahr et al., 2017).

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PDF Deciphering the Role of V88L Substitution in NDM-

Further analysis of the translated amino acid sequences of bla NDM-5 gene revealed that these point mutations resulted in the amino acid substitution involving non-active site residues viz., Valine-88-Leucine (V88L) and Methionine-154-Leucine (M154L).

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Login / Register . Products ; Services ; Digital Solutions ; Applications ; Support ; About ; Order Entry. Order Status. Your Account. Cart. Order Entry. Order Status. Your Account. ... MULTISCREEN™ Human GPBA Mutant V88L CHO-K1 HTS Membranes MULTISCREEN™ Human GPBA Mutant V88L CHO-K1 HTS Membranes . Supplier: MULTISPAN INC.

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Notably, NDM-5 variants harbored V88L and M154L mutations, which are known to increase the fitness of NDM-5 variant towards host immune system and zinc starvation.